Research ArticleCancer

The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer

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Science Translational Medicine  13 Jan 2021:
Vol. 13, Issue 576, eabb3735
DOI: 10.1126/scitranslmed.abb3735

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Respond or not respond

Patients with cancer are frequently treated with chemotherapy, but it does not always work, and it is difficult to predict who will respond to the treatment. In addition to the direct effects of chemotherapy, antitumor immune responses can also play an important role. By examining the immune responses in patients with muscle-invasive bladder cancer, Vollmer et al. identified a key role for the CXCR3 chemokine system of ligands and receptors. The activity of this system before initiation of treatment was associated with subsequent response to chemotherapy in multiple independent cohorts of patients, suggesting a potential rational approach to the selection of therapies.

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