06 January 2021
Vol 13, Issue 575

About The Cover

Cover image expansion

ONLINE COVER Detoxifying Neurotoxins. This image shows a ball-and-stick model of a botulinum neurotoxin (BoNT). BoNTs are bacterial toxins, produced by Clostridium botulinum, that have the ability to enter motor neurons and cause long-lasting paralysis. Targeting BoNTs once they enter cells is challenging, and few treatments are effective. Two complementary studies, Miyashita et al. and McNutt et al., created non-toxic BoNT fragments as a platform to deliver antitoxin antibodies into motor neurons. The approach was effective against BoNT/A and BoNT/B intoxication in mice (Miyashita et al.) and against BoNT/A intoxication in guinea pigs and nonhuman primates (McNutt et al.). This effective approach could be adapted to other therapies targeting intracellular proteins. [CREDIT: MOLEKUUL/SCIENCE SOURCE]