Research ArticleBiosensors

Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses

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Science Translational Medicine  16 Dec 2020:
Vol. 12, Issue 574, eabc4327
DOI: 10.1126/scitranslmed.abc4327

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Form, fit, and function

Improper fit between the prosthetic socket and the residual limb of persons with amputation causes discomfort, pressure ulcers, and altered load bearing. Kwak and colleagues developed pressure and temperature sensors to monitor the interface between a prosthesis and residual limb. The soft sensors communicated wirelessly with portable electronic devices during walking, sitting, and standing in non-amputees wearing prosthesis simulators and in two individuals with transtibial and transfemoral amputation, respectively. Results support use of wireless sensors to monitor the skin-prosthesis interface.


Precise form-fitting of prosthetic sockets is important for the comfort and well-being of persons with limb amputations. Capabilities for continuous monitoring of pressure and temperature at the skin-prosthesis interface can be valuable in the fitting process and in monitoring for the development of dangerous regions of increased pressure and temperature as limb volume changes during daily activities. Conventional pressure transducers and temperature sensors cannot provide comfortable, irritation-free measurements because of their relatively rigid construction and requirements for wired interfaces to external data acquisition hardware. Here, we introduce a millimeter-scale pressure sensor that adopts a soft, three-dimensional design that integrates into a thin, flexible battery-free, wireless platform with a built-in temperature sensor to allow operation in a noninvasive, imperceptible fashion directly at the skin-prosthesis interface. The sensor system mounts on the surface of the skin of the residual limb, in single or multiple locations of interest. A wireless reader module attached to the outside of the prosthetic socket wirelessly provides power to the sensor and wirelessly receives data from it, for continuous long-range transmission to a standard consumer electronic device such as a smartphone or tablet computer. Characterization of both the sensor and the system, together with theoretical analysis of the key responses, illustrates linear, accurate responses and the ability to address the entire range of relevant pressures and to capture skin temperature accurately, both in a continuous mode. Clinical application in two prosthesis users demonstrates the functionality and feasibility of this soft, wireless system.

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