16 December 2020
Vol 12, Issue 574

About The Cover

Cover image expansion

ONLINE COVER SHIELDing the Lung. Infection with SARS-CoV-2, the pathogen that causes COVID-19, can result in serious lung damage. For patients with severe COVID-19, lung transplantation may be their only option for survival (Bharat et al.). The cover image shows biopsies of human lung tissue (x10 magnification) treated with the SHIELD method to reveal the intricate matrix of collagen that provides structure to the lung (blue). The middle image shows healthy lung tissue with a normal collagen matrix, whereas the left and right images reveal complete breakdown of the collagen matrix in lung tissue from two patients with severe COVID-19. [CREDIT: MELISSA QUERREY/NORTHWESTERN UNIVERSITY]