Research ArticleCORONAVIRUS
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
- View ORCID ProfileAlexandra Popa1,*,
- View ORCID ProfileJakob-Wendelin Genger1,*,
- View ORCID ProfileMichael D. Nicholson2,3,4,†,
- Thomas Penz1,†,
- Daniela Schmid5,†,
- Stephan W. Aberle6,†,
- View ORCID ProfileBenedikt Agerer1,†,
- View ORCID ProfileAlexander Lercher1,†,
- View ORCID ProfileLukas Endler7,
- View ORCID ProfileHenrique Colaço1,
- View ORCID ProfileMark Smyth1,
- View ORCID ProfileMichael Schuster1,
- View ORCID ProfileMiguel L. Grau8,
- View ORCID ProfileFrancisco Martínez-Jiménez8,
- View ORCID ProfileOriol Pich8,
- View ORCID ProfileWegene Borena9,
- Erich Pawelka10,
- View ORCID ProfileZsofia Keszei1,
- View ORCID ProfileMartin Senekowitsch1,
- View ORCID ProfileJan Laine1,
- Judith H. Aberle6,
- Monika Redlberger-Fritz6,
- View ORCID ProfileMario Karolyi10,
- Alexander Zoufaly10,
- Sabine Maritschnik5,
- Martin Borkovec5,
- View ORCID ProfilePeter Hufnagl5,
- View ORCID ProfileManfred Nairz11,
- View ORCID ProfileGünter Weiss11,
- View ORCID ProfileMichael T. Wolfinger12,13,
- Dorothee von Laer9,
- Giulio Superti-Furga1,14,
- Nuria Lopez-Bigas8,15,
- Elisabeth Puchhammer-Stöckl6,
- Franz Allerberger5,
- View ORCID ProfileFranziska Michor2,3,4,16,17,18,
- View ORCID ProfileChristoph Bock1,19 and
- View ORCID ProfileAndreas Bergthaler1,‡
- 1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
- 2Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
- 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
- 4Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
- 5Austrian Agency for Health and Food Safety (AGES), 1220 Vienna, Austria.
- 6Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
- 7Bioinformatics and Biostatistics Platform, Department of Biomedical Sciences, University of Veterinary Medicine, 1210 Vienna, Austria.
- 8Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain.
- 9Institute of Virology, Medical University Innsbruck, 6020 Innsbruck, Austria.
- 10Department of Medicine IV, Kaiser Franz Josef Hospital, 1100 Vienna, Austria.
- 11Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
- 12Department of Theoretical Chemistry, University of Vienna, 1090 Vienna, Austria.
- 13Research Group Bioinformatics and Computational Biology, Faculty of Computer Science, University of Vienna, 1090 Vienna, Austria.
- 14Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
- 15Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
- 16Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 17Ludwig Center at Harvard, Boston, MA, USA.
- 18Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, USA.
- 19Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
- ↵‡Corresponding author. Email: abergthaler{at}cemm.oeaw.ac.at
See allHide authors and affiliations
Science Translational Medicine 09 Dec 2020:
Vol. 12, Issue 573, eabe2555
DOI: 10.1126/scitranslmed.abe2555
Vol. 12, Issue 573, eabe2555
DOI: 10.1126/scitranslmed.abe2555
Alexandra Popa
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Jakob-Wendelin Genger
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Michael D. Nicholson
2Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
4Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Thomas Penz
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Daniela Schmid
5Austrian Agency for Health and Food Safety (AGES), 1220 Vienna, Austria.
Stephan W. Aberle
6Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Benedikt Agerer
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Alexander Lercher
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Lukas Endler
7Bioinformatics and Biostatistics Platform, Department of Biomedical Sciences, University of Veterinary Medicine, 1210 Vienna, Austria.
Henrique Colaço
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Mark Smyth
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Michael Schuster
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Miguel L. Grau
8Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain.
Francisco Martínez-Jiménez
8Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain.
Oriol Pich
8Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain.
Wegene Borena
9Institute of Virology, Medical University Innsbruck, 6020 Innsbruck, Austria.
Erich Pawelka
10Department of Medicine IV, Kaiser Franz Josef Hospital, 1100 Vienna, Austria.
Zsofia Keszei
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Martin Senekowitsch
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Jan Laine
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Judith H. Aberle
6Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Monika Redlberger-Fritz
6Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Mario Karolyi
10Department of Medicine IV, Kaiser Franz Josef Hospital, 1100 Vienna, Austria.
Alexander Zoufaly
10Department of Medicine IV, Kaiser Franz Josef Hospital, 1100 Vienna, Austria.
Sabine Maritschnik
5Austrian Agency for Health and Food Safety (AGES), 1220 Vienna, Austria.
Martin Borkovec
5Austrian Agency for Health and Food Safety (AGES), 1220 Vienna, Austria.
Peter Hufnagl
5Austrian Agency for Health and Food Safety (AGES), 1220 Vienna, Austria.
Manfred Nairz
11Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Günter Weiss
11Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Michael T. Wolfinger
12Department of Theoretical Chemistry, University of Vienna, 1090 Vienna, Austria.
13Research Group Bioinformatics and Computational Biology, Faculty of Computer Science, University of Vienna, 1090 Vienna, Austria.
Dorothee von Laer
9Institute of Virology, Medical University Innsbruck, 6020 Innsbruck, Austria.
Giulio Superti-Furga
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
14Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Nuria Lopez-Bigas
8Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain.
15Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Elisabeth Puchhammer-Stöckl
6Center for Virology, Medical University of Vienna, 1090 Vienna, Austria.
Franz Allerberger
5Austrian Agency for Health and Food Safety (AGES), 1220 Vienna, Austria.
Franziska Michor
2Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
4Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
16Broad Institute of MIT and Harvard, Cambridge, MA, USA.
17Ludwig Center at Harvard, Boston, MA, USA.
18Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, USA.
Christoph Bock
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
19Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Andreas Bergthaler
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
