Contents
09 December 2020
Vol 12, Issue 573
Vol 12, Issue 573
Research Articles
- Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
Epidemiological and genomic analyses uncover viral mutational dynamics and transmission bottleneck size during the early COVID-19 pandemic in Austria.
- Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice
Pharmacological induction of wild-type PAX6 allele improved ocular abnormalities induced by PAX6 haploinsufficiency in mice.
Report
- Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs
Agonist-antagonist myoneural interfaces in lower-limb amputation help preserve sensory feedback to the brain.
Research Articles
- Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
Antibody immunodominance to conserved influenza virus epitopes is affected by both preexisting B cell memory and route of exposure.
- An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease
Blocking epoxide hydrolase with a bioavailable small-molecule inhibitor reduces neuropathology in an Alzheimer’s disease mouse model.
- Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy
Cardiosphere-derived exosomes improve cardiac function in dilated cardiomyopathy and provide safety lead-in results for further clinical translation.
Report
- Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy
At 96 weeks after unilateral intravitreal injection of rAAV2/2-ND4, vision improved in both eyes in 78% of subjects affected with LHON.
Editors' Choice
- Convalescent plasma in COVID-19: Does use case matter?
A randomized controlled trial of convalescent plasma in severe COVID-19 shows no benefits.
- Anti-inflammatory drug formulations fight fat
Macrophage-targeted dexamethasone improves weight loss and glucose tolerance not possible with systemic administration of the free drug.
- Re-productive brain stimulation
Kisspeptin agonists restore gonadotropin secretion.
About The Cover
ONLINE COVER Mapping SARS-CoV-2 Mutations. This illustration depicts the phylogenetic relationships among SARS-CoV-2 strains traced to different geographic locales within and beyond Austria, an early international hub for SARS-CoV-2 transmission. Integrating viral genomics and national contact tracing data from Austria in the spring of 2020, Popa et al. tracked the spread of mutations in epidemiologically defined infection clusters, examined intrahost virus evolution, and estimated the SARS-CoV-2 transmission bottleneck size. This study provides a high-resolution picture of virus mutation dynamics and disease spread in an early hotspot of SARS-CoV-2 infection. [CREDIT: JAKOB-WENDELIN GENGER, BERGTHALER LAB/CEMM]
