Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor

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Science Translational Medicine  02 Dec 2020:
Vol. 12, Issue 572, eaay7680
DOI: 10.1126/scitranslmed.aay7680

Article Information

vol. 12 no. 572

Print ISSN: 
Online ISSN: 
  • Received for publication July 17, 2019
  • Resubmitted January 14, 2020
  • Accepted for publication August 25, 2020
  • .

Author Information

  1. Enrico Opri1,*,
  2. Stephanie Cernera1,
  3. Rene Molina2,
  4. Robert S. Eisinger3,
  5. Jackson N. Cagle1,
  6. Leonardo Almeida3,
  7. Timothy Denison4,
  8. Michael S. Okun3,
  9. Kelly D. Foote3, and
  10. Aysegul Gunduz1,2,3,
  1. 1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
  2. 2Electrical and Computer Engineering, University of Florida, Gainesville, FL 32603, USA.
  3. 3Norman Fixel Institute for Neurological Diseases at UF Health, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
  4. 4Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK.
  1. *Corresponding author. Email: enrico.opri{at}
  • This paper was a product of the NIH BRAIN Initiative, and multiple principal investigators A.G. and K.D.F. serve as co-senior authors.


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