Research ArticleBRAIN STIMULATION

Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor

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Science Translational Medicine  02 Dec 2020:
Vol. 12, Issue 572, eaay7680
DOI: 10.1126/scitranslmed.aay7680

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Reducing tremor on-demand

Deep brain stimulation (DBS) has been shown to be effective for treating movement disorders, including essential tremor (ET). Most stimulators work in open-loop mode, applying continuous stimulation with no consideration of patients’ symptoms. Now, Opri et al. developed a closed-loop system for thalamic DBS (CL-DBS) and tested in three patients with ET. CL-DBS delivered the therapeutic stimuli based on upper limb motor activity detected with a cortical electrode. The system was as effective as the open-loop stimulation while preserving energy. The results suggest that CL-DBS could save energy and possibly reduce side effects associated with continuous DBS.

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