02 December 2020
Vol 12, Issue 572

About The Cover

Cover image expansion

ONLINE COVER Fixing Fibrosis. This image shows a colored scanning electron micrograph of human liver fibrosis that occurs during the progression of nonalcoholic fatty liver disease, a currently uncurable condition. Rom et al. found that reduced systemic glycine exacerbated hepatosteatosis and inflammation in diet-induced obese mice. Administration of a glycine-glycine-leucine tripeptide to mice in a model of established nonalcoholic steatohepatitis altered fatty acid oxidation and glutathione synthesis, resulting in improved liver fat, inflammation, and fibrosis. As circulating glycine is often low in patients with nonalcoholic fatty liver disease, such an amino acid–based treatment may hold therapeutic promise for humans. [CREDIT: PIETRO M. MOTTA, TSUNEO FUJITA/SCIENCE SOURCE]