Research ArticleGVHD

Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation

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Science Translational Medicine  25 Nov 2020:
Vol. 12, Issue 571, eaay7713
DOI: 10.1126/scitranslmed.aay7713

Article Information

vol. 12 no. 571

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 17, 2019
  • Resubmitted January 22, 2020
  • Accepted for publication June 2, 2020
  • .

Author Information

  1. Lam T. Khuat1,
  2. Catherine T. Le1,
  3. Chien-Chun Steven Pai1,*,
  4. Robin R. Shields-Cutler2,
  5. Shernan G. Holtan3,
  6. Armin Rashidi3,
  7. Sarah L. Parker4,
  8. Dan Knights5,
  9. Jesus I. Luna1,
  10. Cordelia Dunai1,
  11. Ziming Wang1,
  12. Ian R. Sturgill1,,
  13. Kevin M. Stoffel1,
  14. Alexander A. Merleev1,
  15. Shyam K. More6,
  16. Emanual Maverakis1,
  17. Helen E. Raybould7,
  18. Mingyi Chen8,
  19. Robert J. Canter9,
  20. Arta M. Monjazeb10,
  21. Maneesh Dave6,
  22. James L. M. Ferrara11,
  23. John E. Levine11,
  24. Dan L. Longo12,
  25. Mehrdad Abedi13,
  26. Bruce R. Blazar14 and
  27. William J. Murphy1,13,
  1. 1Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
  2. 2Department of Biology, Macalester College, Saint Paul, MN 55105, USA.
  3. 3Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA.
  4. 4Department of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
  5. 5Department of Computer Science and Engineering, Biotechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA.
  6. 6Division of Gastroenterology, Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
  7. 7Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  8. 8Department of Pathology and Laboratory Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  9. 9Division of Surgical Oncology, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
  10. 10Department of Radiation Oncology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
  11. 11Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  12. 12Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  13. 13Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
  14. 14Masonic Cancer Center and Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
  1. Corresponding author. Email: wmjmurphy{at}ucdavis.edu
  • * Present address: Department of Oncology Biomarker Development, Genentech, South San Francisco, CA, USA.

  • Present address: University of North Carolina at Chapel Hill (as a graduate research assistant).

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