Contents
25 November 2020
Vol 12, Issue 571
Vol 12, Issue 571
Research Articles
- Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans
Endosomal secreted proteins can be detected in the CSF and inform on how Alzheimer’s defective trafficking pathway can contribute to disease spread.
- Systemic cancer therapy with engineered adenovirus that evades innate immunity
Safe and effective “designer” adenoviruses target tumors after systemic administration.
- PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans
A signaling pathway involving the placenta and adipose tissue underlies the development of gestational diabetes.
- Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma
Patients with neuroblastoma infused with GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity.
- Sampling interstitial fluid from human skin using a microneedle patch
Interstitial fluid from skin sampled with a microneedle-based method identified clinically relevant metabolic biomarkers in humans compared to plasma.
- Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation
Obesity and an altered gut microbiota are associated with worsened acute graft-versus-host disease outcomes in mice and humans.
- Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy
A combination of metabolic reprogramming and T cell therapy via surface anchor-engineering results in improved efficacy of immunotherapy in solid tumors.
Editors' Choice
- The metabolic foibles of triple negative breast cancer
Metabolic profiling of triple-negative breast cancers may advance personalized therapies.
- “Gli”-ful neighbors induce epithelial metaplasia
Gli1+ mesenchymal stromal cells induce epithelial metaplasia.
- Modeling the impact of genetic heterogeneity on immunotherapy
A panel of genetically engineered mouse models recapitulates genotype-driven responses to immunotherapy and uncovers a driver of immunotherapy resistance in ovarian cancer.
About The Cover
ONLINE COVER Protein Trafficking. This image represents one of the major hallmarks of Alzheimer's disease (AD): the secretion of proteins from neurons into the extracellular space and subsequent accumulation in the cerebrospinal fluid. AD is characterized by defective retromer-mediated endosomal trafficking that can cause alterations in protein secretion. Simoes et al. developed a mouse model of retromer-dependent endosomal trafficking impairment and identified the proteins that subsequently accumulated in the cerebrospinal fluid. The three most relevant proteins, TAU, APLP1, and CHL1, were then validated in cerebrospinal fluid isolated from patients with AD. The results help to shed light on the mechanisms mediating extracellular protein accumulation in AD. [CREDIT: NICOLETTA BAROLINI]
