Research ArticleCORONAVIRUS

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

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Science Translational Medicine  18 Nov 2020:
Vol. 12, Issue 570, eabd3876
DOI: 10.1126/scitranslmed.abd3876

Casting an autoantibody NET in COVID-19

Patients with severe COVID-19 are at high risk for occlusion of blood vessels of all sizes. This prothrombotic phenotype is reminiscent of patients with lupus and antiphospholipid syndrome, who have long-lived circulating antiphospholipid autoantibodies. In new work, Zuo et al. measured eight types of antiphospholipid antibodies in serum from patients hospitalized with COVID-19 and found at least one antibody in half of patients. Antibody levels were associated with neutrophil and coagulation pathway activation. Purified antibodies from some patients activated neutrophils in vitro and potentiated thrombosis when injected into mice. Together, these findings suggest that autoantibodies are a potential therapeutic target in severe COVID-19.

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