Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

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Science Translational Medicine  18 Nov 2020:
Vol. 12, Issue 570, eabb3791
DOI: 10.1126/scitranslmed.abb3791

Article Information

vol. 12 no. 570

Print ISSN: 
Online ISSN: 
  • Received for publication February 21, 2020
  • Accepted for publication October 30, 2020
  • .

Author Information

  1. David M. P. De Oliveira1,
  2. Lisa Bohlmann1,
  3. Trent Conroy2,
  4. Freda E.-C. Jen2,
  5. Arun Everest-Dass2,
  6. Karl A. Hansford3,
  7. Raghu Bolisetti3,
  8. Ibrahim M. El-Deeb2,
  9. Brian M. Forde1,4,
  10. Minh-Duy Phan1,
  11. Jake A. Lacey5,
  12. Aimee Tan5,
  13. Tania Rivera-Hernandez1,6,
  14. Stephan Brouwer1,
  15. Nadia Keller1,
  16. Timothy J. Kidd1,
  17. Amanda J. Cork1,
  18. Michelle J. Bauer4,
  19. Gregory M. Cook7,
  20. Mark R. Davies5,
  21. Scott A. Beatson1,
  22. David L. Paterson4,
  23. Alastair G. McEwan1,
  24. Jian Li8,
  25. Mark A. Schembri1,
  26. Mark A. T. Blaskovich3,
  27. Michael P. Jennings2,
  28. Christopher A. McDevitt5,*,
  29. Mark von Itzstein2,* and
  30. Mark J. Walker1,*,
  1. 1School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Queensland 4072, Australia.
  2. 2Institute for Glycomics, Griffith University, Queensland 4222, Australia.
  3. 3Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  4. 4Centre for Clinical Research and Australian Infectious Diseases Research Centre, The University of Queensland, Queensland 4029, Australia.
  5. 5Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria 3000, Australia.
  6. 6Consejo Nacional de Ciencia y Tecnología—Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
  7. 7Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand.
  8. 8Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria 3800, Australia.
  1. Corresponding author. Email: mark.walker{at}
  • * These authors contributed equally to this work.


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