Research ArticleRheumatoid Arthritis

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

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Science Translational Medicine  18 Nov 2020:
Vol. 12, Issue 570, eaaz5327
DOI: 10.1126/scitranslmed.aaz5327

Article Information

vol. 12 no. 570

Print ISSN: 
Online ISSN: 
  • Received for publication September 17, 2019
  • Resubmitted June 4, 2020
  • Accepted for publication September 21, 2020
  • .

Author Information

  1. Hendy Kristyanto1,
  2. Nienke J. Blomberg1,
  3. Linda M. Slot1,
  4. Ellen I. H. van der Voort1,
  5. Priscilla F. Kerkman1,2,
  6. Aleida Bakker1,
  7. Leonie E. Burgers1,
  8. Robin M. ten Brinck1,
  9. Annette H. M. van der Helm-van Mil1,
  10. Hergen Spits3,4,
  11. Dominique L. Baeten5,6,
  12. Tom W. J. Huizinga1,
  13. René E. M. Toes1 and
  14. Hans U. Scherer1,*
  1. 1Department of Rheumatology, Leiden University Medical Center, 2300RC Leiden, Netherlands.
  2. 2Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, Netherlands.
  3. 3Department of Experimental Immunology and Amsterdam Institute of Infection and Immunity, Amsterdam University Medical Center, location AMC, 1105AZ Amsterdam, Netherlands.
  4. 4AIMM Therapeutics, 1045BA Amsterdam, Netherlands.
  5. 5Department of Clinical Immunology and Rheumatology, Amsterdam University Medical Center, location AMC, 1105AZ Amsterdam, Netherlands.
  6. 6UCB Pharma, 1070 Brussels, Belgium.
  1. *Corresponding author. Email: h.u.scherer{at}


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