Research ArticleRheumatoid Arthritis

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

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Science Translational Medicine  18 Nov 2020:
Vol. 12, Issue 570, eaaz5327
DOI: 10.1126/scitranslmed.aaz5327

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B cells behaving badly

Anticitrullinated protein antibodies (ACPAs) are present in many individuals with the inflammatory joint disease rheumatoid arthritis (RA). Here, Kristyanto et al. investigated the role of ACPA-positive B cells in the pathogenesis of RA. ACPA-positive B cells had an activated phenotype in individuals with RA and were also present in people with joint pain at risk of developing RA. The ACPA-positive B cells down-regulated the inhibitory receptor CD32 and produced inflammatory neutrophil-recruiting cytokines including interleukin 8. Results reveal a functional role for autoreactive B cells in the pathogenesis of RA.

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