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A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles

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Science Translational Medicine  18 Nov 2020:
Vol. 12, Issue 570, eaay5445
DOI: 10.1126/scitranslmed.aay5445

Article Information

vol. 12 no. 570

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 27, 2019
  • Resubmitted July 17, 2019
  • Accepted for publication October 30, 2020
  • .

Author Information

  1. Jan Claesen1,
  2. Jennifer B. Spagnolo2,3,*,
  3. Stephany Flores Ramos2,*,
  4. Kenji L. Kurita4,,
  5. Allyson L. Byrd5,,
  6. Alexander A. Aksenov6,
  7. Alexey V. Melnik6,
  8. Weng R. Wong7,
  9. Shuo Wang8,
  10. Ryan D. Hernandez7,9,
  11. Mohamed S. Donia10,
  12. Pieter C. Dorrestein6,
  13. Heidi H. Kong11,
  14. Julia A. Segre5,
  15. Roger G. Linington4,
  16. Michael A. Fischbach12,§,|| and
  17. Katherine P. Lemon2,13,14,15,§,||
  1. 1Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  2. 2Microbiology, Forsyth Institute, Cambridge, MA 02142, USA.
  3. 3Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA.
  4. 4Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
  5. 5Microbial Genomics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  6. 6Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, and Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  7. 7Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
  8. 8Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540, USA.
  9. 9Department of Human Genetics, McGill University and Genome Quebec Innovation Center, Montreal, QC H3A 0C7, Canada.
  10. 10Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
  11. 11Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  12. 12Department of Bioengineering and ChEM-H, Stanford University, Stanford, CA 94305, USA.
  13. 13Division of Infectious Diseases, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  14. 14Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  15. 15Section of Infectious Diseases, Department of Pediatrics, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030, USA.
  1. ||Corresponding author. Email: fischbach{at}fischbachgroup.org (M.A.F.); katherine.lemon{at}bcm.edu (K.P.L.)
  • * These authors contributed equally to this work.

  • Present address: Small Molecule Pharmaceutical Sciences, Genentech Inc., San Francisco, CA 94080, USA.

  • Present address: Department of Cancer Immunology, Genentech Inc., San Francisco, CA 94080, USA.

  • § These authors contributed equally to this work.

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