ReportMICROBIOTA

A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles

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Science Translational Medicine  18 Nov 2020:
Vol. 12, Issue 570, eaay5445
DOI: 10.1126/scitranslmed.aay5445

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A microbiota that is only skin deep

Interspecies interactions influence the composition of microbial communities, but their mechanisms are poorly understood. Claesen et al. now identify an antibiotic called cutimycin produced by a ubiquitous member of the human skin and nasal microbiota, Cutibacterium acnes. The authors show that cutimycin inhibited the growth of Staphylococcus in human skin hair follicles, helping to shape the composition of the hair follicle microbiota.

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