Contents
18 November 2020
Vol 12, Issue 570
Vol 12, Issue 570
Research Articles
- Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
Some patients with severe COVID-19 develop prothrombotic autoantibodies that are similar to antiphospholipid antibodies found in autoimmune diseases.
- Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings
GGA3-mediated BACE1 accumulation in dystrophic neurites is an early pathogenic event and is independent of Aβ extracellular deposition.
- Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice
A cAMP-dependent mechanism mediates seizures in mTOR disorders due to the ectopic expression of HCN4 channels in diseased neurons.
- Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease
GVHD includes an autoinflammatory host-versus-graft component from recipient-derived skin-resident memory T cells.
- Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis
Proliferative autoreactive B cells secreting proinflammatory cytokines are associated with early, untreated RA and persist in established disease.
- Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis
The hydroxyquinoline analog PBT2 breaks resistance to polymyxin class antibiotics in polymyxin-resistant Gram-negative bacteria.
Report
- A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles
Cutimycin, a thiopeptide antibiotic produced by the skin commensal Cutibacterium acnes, reduces Staphylococcus colonization of human skin hair follicles.
Editors' Choice
- Aiming the magic bullet
Coadministration of antibody-drug conjugates with the parent antibody improves delivery to solid tumor beds.
- Little things make big things happen
Iron core nanoparticles can serve as vesicle shuttles and be guided by external magnetic fields to deliver therapeutic exosomes to injured tissue.
- TrIgGering inflammation in multiple sclerosis
Myelin-reactive IgG complexes enhance proinflammatory activation of microglia in multiple sclerosis.
About The Cover
ONLINE COVER Casting Autoantibody NETs in COVID-19. Patients with severe COVID-19 are at high risk for occlusion of blood vessels. This prothrombotic phenotype is reminiscent of patients with antiphospholipid syndrome, who have long-lived circulating antiphospholipid autoantibodies. Zuo et al. detected similar serum antiphospholipid autoantibodies in half of the 172 patients they examined, who were hospitalized with severe COVID-19. These antiphospholipid autoantibodies were associated with neutrophil activation and induced thrombosis when injected into mice. The cover depicts how prothrombotic serum autoantibodies (purple) could activate neutrophils (blue), inducing them to release extracellular DNA webs called NETS (yellow) that trap erythrocytes (red) and platelets (pink) leading to blood vessel occlusion. [CREDIT: ERINA HE/NATIONAL INSTITUTES OF HEALTH]
