Research ArticleParkinson’s Disease

Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion

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Science Translational Medicine  11 Nov 2020:
Vol. 12, Issue 569, eaax0091
DOI: 10.1126/scitranslmed.aax0091

Article Information

vol. 12 no. 569

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 15, 2019
  • Resubmitted April 3, 2020
  • Accepted for publication July 9, 2020
  • .

Author Information

  1. Sangwoo Ham1,2,
  2. Seung Pil Yun3,4,
  3. Hyojung Kim1,
  4. Donghoon Kim3,4,
  5. Bo Am Seo3,4,
  6. Heejeong Kim1,
  7. Jeong-Yong Shin1,
  8. Mohamad Aasif Dar3,4,
  9. Gum Hwa Lee5,
  10. Yun Il Lee6,7,
  11. Doyeun Kim8,9,
  12. Sunghoon Kim8,9,
  13. Hee-Seok Kweon10,
  14. Joo-Ho Shin1,
  15. Han Seok Ko3,4,* and
  16. Yunjong Lee1,*,
  1. 1Division of Pharmacology, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute (SBRI), Suwon 16419, Republic of Korea.
  2. 2ToolGen Inc., Seoul 08501, Republic of Korea.
  3. 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  4. 4Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  5. 5College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
  6. 6Well Aging Research Center, DGIST, Daegu 42988, Republic of Korea.
  7. 7Companion Diagnostics and Medical Technology Research Group, DGIST, Daegu 42988, Republic of Korea.
  8. 8Medicinal Bioconvergence Research Center, Yonsei University, Incheon 21983, Republic of Korea.
  9. 9College of Pharmacy and School of Medicine, Yonsei University, Incheon 21983, Republic of Korea.
  10. 10Center for Research Equipment, Korea Basic Science Institute, Cheongju 28119, Republic of Korea.
  1. *Corresponding author. Email: ylee69{at}skku.edu (Y.L.); hko3{at}jhmi.edu (H.S.K.)
  • Lead contact.

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