11 November 2020
Vol 12, Issue 569

About The Cover

Cover image expansion

ONLINE COVER Improper Aggregation. This image shows the ultrastructure of an α-synuclein aggregate. Lewy bodies are toxic protein aggregates composed of α-synuclein and other accessory proteins that develop in the brains of patients with neurodegenerative diseases. In this study, Ham et al. discovered that aminoacyl transfer RNA synthetase complex–interacting multifunctional protein-2 (AIMP2) plays a critical role in Lewy body formation by both self-aggregating and increasing the aggregating properties of α-synuclein. These findings suggest that AIMP2 might be an effective target for reducing the formation of Lewy bodies in neurodegenerative diseases. [CREDIT: HAM ET AL./SCIENCE TRANSLATIONAL MEDICINE]