Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans

Jennifer A. Jenks; Cody S. Nelson; Hunter K. Roark; Matthew L. Goodwin; Robert F. Pass; David I. Bernstein; Emmanuel B. Walter; Kathryn M. Edwards; Dai Wang; Tong-Ming Fu; Zhiqiang An; Cliburn Chan; Sallie R. Permar

doi:10.1126/scitranslmed.abb3611

Research ArticleVaccines

Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans

View ORCID ProfileJennifer A. Jenks¹,
View ORCID ProfileCody S. Nelson ¹,²,
Hunter K. Roark¹,
View ORCID ProfileMatthew L. Goodwin¹,
View ORCID ProfileRobert F. Pass³,
David I. Bernstein⁴,
Emmanuel B. Walter¹,
Kathryn M. Edwards⁵,
View ORCID ProfileDai Wang⁶,
View ORCID ProfileTong-Ming Fu⁷,
View ORCID ProfileZhiqiang An⁷,
View ORCID ProfileCliburn Chan⁸,* and
View ORCID ProfileSallie R. Permar ¹,⁹,*,†

¹Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.
²Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
³Department of Pediatrics, University of Alabama of Birmingham, Birmingham, AL 35233, USA.
⁴Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
⁵Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
⁶Merck & Co. Inc., Kenilworth, NJ 07033, USA.
⁷Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
⁸Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27705, USA.
⁹Department of Pediatrics, Duke University Medical Center, Durham, NC 27705, USA.

↵†Corresponding author. Email: sallie.permar{at}duke.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 04 Nov 2020:
Vol. 12, Issue 568, eabb3611
DOI: 10.1126/scitranslmed.abb3611

Jennifer A. Jenks

1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.

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Cody S. Nelson

1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.

2Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Hunter K. Roark

1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.

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Matthew L. Goodwin

1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.

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Robert F. Pass

3Department of Pediatrics, University of Alabama of Birmingham, Birmingham, AL 35233, USA.

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David I. Bernstein

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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Emmanuel B. Walter

1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.

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Kathryn M. Edwards

5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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Dai Wang

6Merck & Co. Inc., Kenilworth, NJ 07033, USA.

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Tong-Ming Fu

7Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.

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Zhiqiang An

7Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.

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Cliburn Chan

8Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27705, USA.

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Sallie R. Permar

1Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27705, USA.

9Department of Pediatrics, Duke University Medical Center, Durham, NC 27705, USA.

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For correspondence: sallie.permar@duke.edu

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Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans

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