Research ArticleCancer

iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy

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Science Translational Medicine  04 Nov 2020:
Vol. 12, Issue 568, eaaz5618
DOI: 10.1126/scitranslmed.aaz5618

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Unleashing the killer in stem cells

Immune checkpoint blockade and other immunotherapies for cancer have shown promising results but are still limited in their effectiveness. Adding natural killer cells to immunotherapy regimens offers some promise in this regard, but it can be limited by cell availability. To overcome this constraint, Cichocki et al. developed a method for manufacturing natural killer cells from induced pluripotent stem cells. These manufactured natural killer cells produced inflammatory cytokines, killed tumor cells, and cooperated effectively with antitumor T cells both in vitro and in mouse models, supporting their potential as an off-the-shelf anticancer treatment.

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