04 November 2020
Vol 12, Issue 568

About The Cover

Cover image expansion

ONLINE COVER Restoring Tolerance. This image depicts co-localization (yellow) of two myelin-relevant proteins, myelin basic protein (green) and glycoprotein (red), in a mature mouse oligodendrocyte. Antigens derived from myelin-relevant proteins may be targets of immune responses in multiple sclerosis (MS), an autoimmune demyelinating disease that affects the central nervous system. Casella et al. demonstrated that mouse and human oligodendrocyte-derived extracellular vesicles (Ol-EVs) contained myelin-relevant antigens. Treatment with Ol-EVs in a mouse model of autoimmune encephalomyelitis restored immune tolerance and reduced symptoms of disease. The results suggest that Ol-EVs might be effective in inducing antigen-specific immune tolerance in patients with MS. [CREDIT: CASELLA ET AL./SCIENCE TRANSLATIONAL MEDICINE]