Contents
04 November 2020
Vol 12, Issue 568
Vol 12, Issue 568
Editorial
- Courage in a climate of fear
It is essential for physicians and scientists to speak up to counter misinformation about COVID-19 amid a culture of fear.
Review
- Prospects for a safe COVID-19 vaccine
Prior vaccine development experiences do not raise concerns about vaccine-associated enhanced disease for COVID-19 vaccine candidates.
Research Articles
- Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice
Extracellular vesicles from oligodendrocytes restore antigen-specific immune tolerance in mice models of multiple sclerosis.
- Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis
Multimodal intravital microscopy and PET imaging of S. aureus endocarditis can monitor adjuvant immunotherapy in mice and pigs.
- iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti–PD-1 therapy
Natural killer cells derived from iPSCs prime T cells for anti–PD-1 immune checkpoint therapy.
- Evaluating the evidence for a neuroimaging subtype of posttraumatic stress disorder
The search for neuroimaging and cognition-based subgroups of posttraumatic stress disorder illustrates the power and pitfalls of this approach.
- Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans
Protection against CMV correlates with gB/MF59 vaccine-elicited IgG that binds cell-associated gB.
- A decision algorithm to promote outpatient antimicrobial stewardship for uncomplicated urinary tract infection
Machine learning models for predicting antibiotic resistance could reduce the use of broad-spectrum antibiotics in urinary tract infection.
Editors' Choice
- A spicy solution for sickle cell disease
In mice with sickle cell disease, signaling through the capsaicin receptor appears to mitigate vaso-occlusive episodes and organ damage.
- Partners in crime: α-synuclein modulates pathologic tau spreading
Coadministration of fibrillar α-synuclein along with brain-derived tau seeds exacerbates tau spreading in mice.
- More than just a platelet factory
Megakaryocytes are found in the lungs of mice and nonhuman primates, where they have a tissue-dependent antigen-presenting cell role and can activate CD4+ T cells.
About The Cover
ONLINE COVER Restoring Tolerance. This image depicts co-localization (yellow) of two myelin-relevant proteins, myelin basic protein (green) and glycoprotein (red), in a mature mouse oligodendrocyte. Antigens derived from myelin-relevant proteins may be targets of immune responses in multiple sclerosis (MS), an autoimmune demyelinating disease that affects the central nervous system. Casella et al. demonstrated that mouse and human oligodendrocyte-derived extracellular vesicles (Ol-EVs) contained myelin-relevant antigens. Treatment with Ol-EVs in a mouse model of autoimmune encephalomyelitis restored immune tolerance and reduced symptoms of disease. The results suggest that Ol-EVs might be effective in inducing antigen-specific immune tolerance in patients with MS. [CREDIT: CASELLA ET AL./SCIENCE TRANSLATIONAL MEDICINE]
