Research ArticleCancer

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

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Science Translational Medicine  28 Oct 2020:
Vol. 12, Issue 567, eabb8969
DOI: 10.1126/scitranslmed.abb8969

Article Information

vol. 12 no. 567

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 25, 2020
  • Accepted for publication September 10, 2020
  • .

Author Information

  1. Franziska M. Uhl1,2,
  2. Sophia Chen1,3,
  3. David O’Sullivan4,
  4. Joy Edwards-Hicks4,
  5. Gesa Richter5,
  6. Eileen Haring1,2,
  7. Geoffroy Andrieux6,7,
  8. Sebastian Halbach8,
  9. Petya Apostolova1,4,
  10. Jörg Büscher4,
  11. Sandra Duquesne1,
  12. Wolfgang Melchinger1,
  13. Barbara Sauer1,
  14. Khalid Shoumariyeh1,
  15. Annette Schmitt-Graeff9,
  16. Marina Kreutz10,11,
  17. Michael Lübbert1,
  18. Justus Duyster1,
  19. Tilman Brummer7,8,
  20. Melanie Boerries6,7,
  21. Tobias Madl5,12,
  22. Bruce R. Blazar13,
  23. Olaf Groß14,15,
  24. Erika L. Pearce4 and
  25. Robert Zeiser1,15,*
  1. 1Department of Internal Medicine I, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
  2. 2Faculty of Biology, University of Freiburg, Freiburg 79104, Germany.
  3. 3Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  4. 4Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.
  5. 5Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology & Biochemistry, Medical University of Graz, Graz 8010, Austria.
  6. 6Institute of Medical Bioinformatics and Systems Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany.
  7. 7German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
  8. 8Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
  9. 9University of Freiburg, Freiburg 79085, Germany.
  10. 10Internal Medicine III, University Hospital Regensburg, Regensburg 93042, Germany.
  11. 11Regensburg Center for Interventional Immunology (RCI), Regensburg 93053, Germany.
  12. 12BioTechMed-Graz, Graz 8010, Austria.
  13. 13Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
  14. 14Institute of Neuropathology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
  15. 15Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg 79106, Germany.
  1. *Corresponding author. Email: robert.zeiser{at}uniklinik-freiburg.de

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