Research ArticleCancer

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

See allHide authors and affiliations

Science Translational Medicine  28 Oct 2020:
Vol. 12, Issue 567, eabb8969
DOI: 10.1126/scitranslmed.abb8969

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

A basic treatment for leukemia

For patients with acute myeloid leukemia, hematopoietic stem cell transplant offers a chance of curing the underlying cancer, in part because of the graft-versus-leukemia effect, or anticancer activity of transplanted T cells. Unfortunately, this does not always work, and engrafted T cells often fail to control the leukemia. By studying patients with acute myeloid leukemia who relapsed after hematopoietic stem cell transplant, Uhl et al. found that lactic acid produced by leukemic cells specifically interfered with T cell activity. The detrimental effects of lactic acid could be overcome with sodium bicarbonate, which improved T cell metabolic fitness in both mouse models and human patients.

View Full Text

Stay Connected to Science Translational Medicine