Research ArticleCHAGAS DISEASE

A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease

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Science Translational Medicine  28 Oct 2020:
Vol. 12, Issue 567, eabb7656
DOI: 10.1126/scitranslmed.abb7656

Trouncing trypanosomes

Trypanosoma cruzi infection causes Chagas disease in millions of individuals in Latin America, and intensive drug treatment is frequently unsuccessful. Bustamante et al. demonstrated that high weekly doses of oral benznidazole over 30 weeks, rather than the current treatment of smaller twice-daily doses over 2 months, resulted in better clearance of both actively replicating and dormant trypanosomes in mouse models of Chagas disease. The clearance of dormant parasites was confirmed by light sheet fluorescence microscopy, which allowed the authors to image whole organs and intact tissues of infected mice. Further studies will determine if this drug regimen will be successful for treating those with Chagas disease.

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