Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum

Kevin M. Vannella; Sydney Stein; Mark Connelly; Joanna Swerczek; Emerito Amaro-Carambot; Elizabeth M. Coyle; Ashley Babyak; Clayton W. Winkler; Greg Saturday; Neville D. Gai; Dima A. Hammoud; Kimberly A. Dowd; Luis Perez Valencia; Marcos J. Ramos-Benitez; Jason Kindrachuk; Theodore C. Pierson; Karin E. Peterson; Jason M. Brenchley; Steve S. Whitehead; Surender Khurana; Richard Herbert; Daniel S. Chertow

doi:10.1126/scitranslmed.aaz4997

Research ArticleVIRAL DISEASE

Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum

View ORCID ProfileKevin M. Vannella¹,²,
View ORCID ProfileSydney Stein¹,²,
Mark Connelly¹,²,
View ORCID ProfileJoanna Swerczek³,
Emerito Amaro-Carambot⁴,
Elizabeth M. Coyle⁵,
Ashley Babyak¹,²,
View ORCID ProfileClayton W. Winkler⁶,
Greg Saturday⁷,
Neville D. Gai⁸,
Dima A. Hammoud⁸,
View ORCID ProfileKimberly A. Dowd⁹,
View ORCID ProfileLuis Perez Valencia¹,²,
Marcos J. Ramos-Benitez¹,²,
View ORCID ProfileJason Kindrachuk¹,²,¹⁰,
View ORCID ProfileTheodore C. Pierson⁹,
View ORCID ProfileKarin E. Peterson⁶,
Jason M. Brenchley¹¹,
View ORCID ProfileSteve S. Whitehead⁴,
View ORCID ProfileSurender Khurana⁵,
Richard Herbert³ and
View ORCID ProfileDaniel S. Chertow¹,²,*

¹Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
²Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
³Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, MD 20837, USA.
⁴Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁵Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.
⁶Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
⁷Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
⁸Center for Infectious Disease Imaging, Radiology and Imaging Services, National Institutes of Health, Bethesda, MD 20892, USA.
⁹Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
¹⁰Laboratory of Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
¹¹Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

↵*Corresponding author. Email: chertowd{at}cc.nih.gov

See allHide authors and affiliations

Science Translational Medicine 28 Oct 2020:
Vol. 12, Issue 567, eaaz4997
DOI: 10.1126/scitranslmed.aaz4997

Kevin M. Vannella

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kevin M. Vannella

Sydney Stein

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sydney Stein

Mark Connelly

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joanna Swerczek

3Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, MD 20837, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joanna Swerczek

Emerito Amaro-Carambot

4Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Elizabeth M. Coyle

5Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ashley Babyak

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Clayton W. Winkler

6Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Clayton W. Winkler

Greg Saturday

7Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Neville D. Gai

8Center for Infectious Disease Imaging, Radiology and Imaging Services, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Dima A. Hammoud

8Center for Infectious Disease Imaging, Radiology and Imaging Services, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kimberly A. Dowd

9Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kimberly A. Dowd

Luis Perez Valencia

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Luis Perez Valencia

Marcos J. Ramos-Benitez

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jason Kindrachuk

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

10Laboratory of Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jason Kindrachuk

Theodore C. Pierson

9Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Theodore C. Pierson

Karin E. Peterson

6Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Karin E. Peterson

Jason M. Brenchley

11Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Steve S. Whitehead

4Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Steve S. Whitehead

Surender Khurana

5Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Surender Khurana

Richard Herbert

3Experimental Primate Virology Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Poolesville, MD 20837, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Daniel S. Chertow

1Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

2Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Daniel S. Chertow
For correspondence: chertowd@cc.nih.gov

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools