Research ArticleVIRAL DISEASE

Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum

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Science Translational Medicine  28 Oct 2020:
Vol. 12, Issue 567, eaaz4997
DOI: 10.1126/scitranslmed.aaz4997

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Elucidating Zika virus immune responses in macaque infants

Infants exposed to Zika virus in utero can develop severe neurological abnormalities after birth. However, little is known about the ability of infants to produce immune responses against Zika virus. Vannella and colleagues followed four asymptomatic nonhuman primate infants that were born to mothers infected with Zika virus during pregnancy. All four produced antiviral immune responses, but these responses did not protect the animals against another Zika virus infection 1 year after birth. Given the similarity of nonhuman primates to humans, these results provide new insights that may apply to the postnatal susceptibility of asymptomatic human offspring born to Zika virus–infected mothers.

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