Research ArticleColitis

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

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Science Translational Medicine  28 Oct 2020:
Vol. 12, Issue 567, eaay6218
DOI: 10.1126/scitranslmed.aay6218

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Harmful sweetness

Inflammatory bowel diseases (IBDs) include multiple disorders characterized by chronic gastrointestinal inflammation. Although the etiology of these diseases is mostly unknown, Western diet and lifestyle seem to be associated with higher IBD incidence. Here, Khan et al. studied the effect of high-sugar diet on colitis in rodent models and showed that a diet high in simple sugars aggravated colitis in mouse models when administered before or after colitis induction. The effect was mediated by alteration of gut microbiota, with an increase of mucolytic bacteria that facilitated gut mucus barrier degradation. The results suggest that high-sugar diet might promote gut microbiota dysfunction and IBD development.

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