Research ArticlePulmonary fibrosis

Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models

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Science Translational Medicine  28 Oct 2020:
Vol. 12, Issue 567, eaay3724
DOI: 10.1126/scitranslmed.aay3724

Article Information

vol. 12 no. 567

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 14, 2019
  • Resubmitted November 24, 2019
  • Accepted for publication June 29, 2020
  • .

Author Information

  1. Suraj U. Hettiarachchi1,
  2. Yen-Hsing Li1,
  3. Jyoti Roy1,
  4. Fenghua Zhang1,
  5. Estela Puchulu-Campanella1,
  6. Spencer D. Lindeman1,
  7. Madduri Srinivasarao1,
  8. Konstantin Tsoyi2,3,
  9. Xiaoliang Liang2,3,
  10. Ehab A. Ayaub2,
  11. Cheryl Nickerson-Nutter4,
  12. Ivan O. Rosas2,3 and
  13. Philip S. Low1,*
  1. 1Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
  2. 2Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
  4. 4Three Lakes Foundation, Northbrook, IL 60062, USA.
  1. *Corresponding author. Email: plow{at}purdue.edu

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