Contents
28 October 2020
Vol 12, Issue 567
Vol 12, Issue 567
Research Articles
- Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice
High-sugar diet promotes the growth of mucolytic bacteria, leading to reduction of the mucus layer and predisposition to colitis in mice.
- Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity
Mohawk is enriched in meniscal tissue and promotes meniscus cell phenotype, enhances repair, and protects against cartilage destruction in mice.
- A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease
A modified regimen of benznidazole prevents Trypanosoma cruzi dormancy-dependent treatment failure in several mouse models of Chagas disease.
- Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum
Macaques exposed to Zika virus in utero mount a Zika virus–specific immune response that is not protective against reinfection 1 year after birth.
- Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans
Bicarbonate boosts metabolic fitness of T cells challenged with leukemia-derived lactic acid.
- A probiotic yeast-based immunotherapy against Clostridioides difficile infection
An engineered yeast-based immunotherapy shows prophylactic and therapeutic efficacy against C. difficile infection in mice.
- Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models
Inhibition of phosphatidylinositol 3-kinase in lung myofibroblasts reduced symptoms of IPF in rodents and in vitro human samples.
Editors' Choice
- Bispecific CAR T cells have a dual grasp on tumors
Bispecific CD19/CD20 chimeric antigen receptor T cells show high efficacy in B cell malignancies.
- Early stage EGFR-mutated lung cancer gets a targeted treatment
Osimertinib improves disease-free survival for patients with early stage EGFR-mutated non-small cell lung cancer after complete tumor resection.
- Encapsulating a leukemia vaccine
A self-healing microcapsule loaded with leukemia-associated antigens, epitope peptides, and PD-1 antibody demonstrates sustained delivery of a leukemia vaccine.
Erratum
About The Cover
ONLINE COVER Low Sugar for a Healthy Gut. This image shows mucin (green) and intestinal bacteria (red) in a section of colon tissue from a mouse fed a high-sugar diet. A Western diet, characterized by elevated sugar content, is associated with higher incidence of inflammatory bowel disease (IBD). Studying the link between sugar and IBD, Khan et al. fed mice either a standard diet or a high-sugar diet before inducing colonic inflammation. Animals fed a high-sugar diet developed more severe disease due to alterations in the gut microbiome. High-sugar diet promoted the growth of mucus-degrading bacteria that facilitated intestinal barrier damage. The results suggest that sugar might play a major role in triggering IBD. [CREDIT: KHAN ET AL./SCIENCE TRANSLATIONAL MEDICINE]
