28 October 2020
Vol 12, Issue 567

About The Cover

Cover image expansion

ONLINE COVER Low Sugar for a Healthy Gut. This image shows mucin (green) and intestinal bacteria (red) in a section of colon tissue from a mouse fed a high-sugar diet. A Western diet, characterized by elevated sugar content, is associated with higher incidence of inflammatory bowel disease (IBD). Studying the link between sugar and IBD, Khan et al. fed mice either a standard diet or a high-sugar diet before inducing colonic inflammation. Animals fed a high-sugar diet developed more severe disease due to alterations in the gut microbiome. High-sugar diet promoted the growth of mucus-degrading bacteria that facilitated intestinal barrier damage. The results suggest that sugar might play a major role in triggering IBD. [CREDIT: KHAN ET AL./SCIENCE TRANSLATIONAL MEDICINE]