Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

Bruno Lamas; Leticia Hernandez-Galan; Heather J. Galipeau; Marco Constante; Alexandra Clarizio; Jennifer Jury; Natalia M. Breyner; Alberto Caminero; Gaston Rueda; Christina L. Hayes; Justin L. McCarville; Miriam Bermudez Brito; Julien Planchais; Nathalie Rolhion; Joseph A. Murray; Philippe Langella; Linda M. P. Loonen; Jerry M. Wells; Premysl Bercik; Harry Sokol; Elena F. Verdu

doi:10.1126/scitranslmed.aba0624

Research ArticleCeliac Disease

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

View ORCID ProfileBruno Lamas¹,*,
Leticia Hernandez-Galan¹,*,
View ORCID ProfileHeather J. Galipeau¹,
View ORCID ProfileMarco Constante¹,
View ORCID ProfileAlexandra Clarizio¹,
View ORCID ProfileJennifer Jury¹,
View ORCID ProfileNatalia M. Breyner¹,
View ORCID ProfileAlberto Caminero¹,
Gaston Rueda¹,
View ORCID ProfileChristina L. Hayes¹,
Justin L. McCarville¹,
Miriam Bermudez Brito¹,
View ORCID ProfileJulien Planchais²,
Nathalie Rolhion³,
Joseph A. Murray⁴,
Philippe Langella²,
View ORCID ProfileLinda M. P. Loonen⁵,
Jerry M. Wells ⁵,
View ORCID ProfilePremysl Bercik¹,
View ORCID ProfileHarry Sokol ²,³,†,‡ and
View ORCID ProfileElena F. Verdu ¹,†,‡

¹Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
²Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France.
³Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Service de Gastroenterologie, F-75012 Paris, France.
⁴Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.
⁵Host-Microbe Interactomics, Animal Sciences Group, Wageningen University, Wageningen, Netherlands.

↵‡Corresponding author. Email: verdue{at}mcmaster.ca (E.F.V.); harry.sokol{at}aphp.fr (H.S.)

↵* These authors contributed to this work as co-first authors.
↵† These authors contributed to this work as co-senior authors.

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Science Translational Medicine 21 Oct 2020:
Vol. 12, Issue 566, eaba0624
DOI: 10.1126/scitranslmed.aba0624

Bruno Lamas

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Leticia Hernandez-Galan

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Heather J. Galipeau

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Marco Constante

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Alexandra Clarizio

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Jennifer Jury

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Natalia M. Breyner

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Alberto Caminero

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Gaston Rueda

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Christina L. Hayes

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Justin L. McCarville

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Miriam Bermudez Brito

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Julien Planchais

2Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France.

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Nathalie Rolhion

3Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Service de Gastroenterologie, F-75012 Paris, France.

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Joseph A. Murray

4Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.

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Philippe Langella

2Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France.

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Linda M. P. Loonen

5Host-Microbe Interactomics, Animal Sciences Group, Wageningen University, Wageningen, Netherlands.

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Jerry M. Wells

5Host-Microbe Interactomics, Animal Sciences Group, Wageningen University, Wageningen, Netherlands.

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Premysl Bercik

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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Harry Sokol

2Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France.

3Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Service de Gastroenterologie, F-75012 Paris, France.

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For correspondence: verdue@mcmaster.ca harry.sokol@aphp.fr

Elena F. Verdu

1Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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For correspondence: verdue@mcmaster.ca harry.sokol@aphp.fr

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Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

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