Research ArticleTissue Engineering

Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration

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Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eabb6683
DOI: 10.1126/scitranslmed.abb6683

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Tempering troublesome joints

Temporomandibular joint (TMJ) dysfunction is a common affliction of the jaw that can cause painful interference with chewing or movement, sometimes requiring surgical intervention. Chen et al. sought to reconstruct the cartilage and bone components of the ramus-condyle unit of the TMJ. Using bioreactor culture of autologous cells, they showed that engineered complex tissue grafts repaired TMJ defects in minipigs over 6 months. Results demonstrate the importance of regeneration of the cartilage layer overlying the bone of the constructs for recapitulation of native-like tissue morphology and biochemical composition, as well as long-term function.

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