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Research ArticleDrug Delivery
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
- View ORCID ProfileMalin Bern1,2,
- View ORCID ProfileJeannette Nilsen1,2,*,
- View ORCID ProfileMattia Ferrarese3,*,
- View ORCID ProfileKine M. K. Sand1,2,4,*,
- Torleif T. Gjølberg1,2,5,†,
- View ORCID ProfileHeidrun E. Lode1,2,5,†,
- Robert J. Davidson6,
- Rodney M. Camire6,7,
- Espen S. Bækkevold8,
- View ORCID ProfileStian Foss1,2,
- View ORCID ProfileAlgirdas Grevys1,2,
- View ORCID ProfileBjørn Dalhus9,
- John Wilson10,
- View ORCID ProfileLene S. Høydahl1,11,
- View ORCID ProfileGregory J. Christianson10,
- View ORCID ProfileDerry C. Roopenian10,
- Tilman Schlothauer12,
- View ORCID ProfileTerje E. Michaelsen13,14,
- View ORCID ProfileMorten C. Moe5,
- View ORCID ProfileSilvia Lombardi3,
- View ORCID ProfileMirko Pinotti3,
- Inger Sandlie1,4,
- View ORCID ProfileAlessio Branchini3,‡ and
- View ORCID ProfileJan Terje Andersen1,2,‡
- 1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
- 2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
- 3Department of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
- 4CIR and Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
- 5Department of Ophthalmology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0450 Oslo, Norway.
- 6The Children’s Hospital of Philadelphia, The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Philadelphia, PA 19104, USA.
- 7Department of Pediatrics, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 8CIR and Department of Pathology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
- 9Department for Medical Biochemistry, Institute for Clinical Medicine and Department for Microbiology, Clinic for Laboratory Medicine, University of Oslo, 0372 Oslo, Norway.
- 10The Jackson Laboratory, Bar Harbor, ME 04609, USA.
- 11KG Jebsen Coeliac Disease Research Centre, University of Oslo, 0372 Oslo, Norway.
- 12Biochemical and Analytical Research, Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, 82377 Penzberg, Germany.
- 13Department of Infectious Disease Immunology, Norwegian Institute of Public Health, 0456 Oslo, Norway.
- 14Department of Chemical Pharmacy, School of Pharmacy, University of Oslo, 0371 Oslo, Norway.
- ↵‡Corresponding author. Email: j.t.andersen{at}medisin.uio.no (J.T.A.); brnlss{at}unife.it (A.B.).
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Science Translational Medicine 14 Oct 2020:
Vol. 12, Issue 565, eabb0580
DOI: 10.1126/scitranslmed.abb0580
Vol. 12, Issue 565, eabb0580
DOI: 10.1126/scitranslmed.abb0580
Malin Bern
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
Jeannette Nilsen
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
Mattia Ferrarese
3Department of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
Kine M. K. Sand
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
4CIR and Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
Torleif T. Gjølberg
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
5Department of Ophthalmology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0450 Oslo, Norway.
Heidrun E. Lode
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
5Department of Ophthalmology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0450 Oslo, Norway.
Robert J. Davidson
6The Children’s Hospital of Philadelphia, The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Philadelphia, PA 19104, USA.
Rodney M. Camire
6The Children’s Hospital of Philadelphia, The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Philadelphia, PA 19104, USA.
7Department of Pediatrics, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Espen S. Bækkevold
8CIR and Department of Pathology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
Stian Foss
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
Algirdas Grevys
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
Bjørn Dalhus
9Department for Medical Biochemistry, Institute for Clinical Medicine and Department for Microbiology, Clinic for Laboratory Medicine, University of Oslo, 0372 Oslo, Norway.
John Wilson
10The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Lene S. Høydahl
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
11KG Jebsen Coeliac Disease Research Centre, University of Oslo, 0372 Oslo, Norway.
Gregory J. Christianson
10The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Derry C. Roopenian
10The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Tilman Schlothauer
12Biochemical and Analytical Research, Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, 82377 Penzberg, Germany.
Terje E. Michaelsen
13Department of Infectious Disease Immunology, Norwegian Institute of Public Health, 0456 Oslo, Norway.
14Department of Chemical Pharmacy, School of Pharmacy, University of Oslo, 0371 Oslo, Norway.
Morten C. Moe
5Department of Ophthalmology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0450 Oslo, Norway.
Silvia Lombardi
3Department of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
Mirko Pinotti
3Department of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
Inger Sandlie
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
4CIR and Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
Alessio Branchini
3Department of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
Jan Terje Andersen
1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
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