Research ArticleDrug Delivery

An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics

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Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eabb0580
DOI: 10.1126/scitranslmed.abb0580

Article Information

vol. 12 no. 565

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 24, 2020
  • Accepted for publication September 24, 2020
  • .

Author Information

  1. Malin Bern1,2,
  2. Jeannette Nilsen1,2,*,
  3. Mattia Ferrarese3,*,
  4. Kine M. K. Sand1,2,4,*,
  5. Torleif T. Gjølberg1,2,5,,
  6. Heidrun E. Lode1,2,5,,
  7. Robert J. Davidson6,
  8. Rodney M. Camire6,7,
  9. Espen S. Bækkevold8,
  10. Stian Foss1,2,
  11. Algirdas Grevys1,2,
  12. Bjørn Dalhus9,
  13. John Wilson10,
  14. Lene S. Høydahl1,11,
  15. Gregory J. Christianson10,
  16. Derry C. Roopenian10,
  17. Tilman Schlothauer12,
  18. Terje E. Michaelsen13,14,
  19. Morten C. Moe5,
  20. Silvia Lombardi3,
  21. Mirko Pinotti3,
  22. Inger Sandlie1,4,
  23. Alessio Branchini3, and
  24. Jan Terje Andersen1,2,
  1. 1Centre for Immune Regulation (CIR) and Department of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
  2. 2Institute of Clinical Medicine and Department of Pharmacology, University of Oslo and Oslo University Hospital, 0372 Oslo, Norway.
  3. 3Department of Life Sciences and Biotechnology and LTTA, University of Ferrara, 44121 Ferrara, Italy.
  4. 4CIR and Department of Biosciences, University of Oslo, 0371 Oslo, Norway.
  5. 5Department of Ophthalmology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0450 Oslo, Norway.
  6. 6The Children’s Hospital of Philadelphia, The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Philadelphia, PA 19104, USA.
  7. 7Department of Pediatrics, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  8. 8CIR and Department of Pathology, University of Oslo and Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway.
  9. 9Department for Medical Biochemistry, Institute for Clinical Medicine and Department for Microbiology, Clinic for Laboratory Medicine, University of Oslo, 0372 Oslo, Norway.
  10. 10The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  11. 11KG Jebsen Coeliac Disease Research Centre, University of Oslo, 0372 Oslo, Norway.
  12. 12Biochemical and Analytical Research, Large Molecule Research, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Munich, 82377 Penzberg, Germany.
  13. 13Department of Infectious Disease Immunology, Norwegian Institute of Public Health, 0456 Oslo, Norway.
  14. 14Department of Chemical Pharmacy, School of Pharmacy, University of Oslo, 0371 Oslo, Norway.
  1. Corresponding author. Email: j.t.andersen{at}medisin.uio.no (J.T.A.); brnlss{at}unife.it (A.B.).
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

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