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Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors

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Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eabb0391
DOI: 10.1126/scitranslmed.abb0391

Article Information

vol. 12 no. 565

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 24, 2020
  • Accepted for publication August 13, 2020
  • .

Author Information

  1. Iván Márquez-Rodas1,*,
  2. Federico Longo2,
  3. Maria E. Rodriguez-Ruiz3,
  4. Antonio Calles1,
  5. Santiago Ponce4,
  6. Maria Jove5,
  7. Belén Rubio-Viqueira6,
  8. Jose Luis Perez-Gracia7,
  9. Ana Gómez-Rueda2,
  10. Sara López-Tarruella1,
  11. Mariano Ponz-Sarvise3,
  12. Rosa Álvarez1,
  13. Ainara Soria-Rivas2,
  14. Enrique de Miguel8,
  15. Rocío Ramos-Medina1,
  16. Eduardo Castañon7,
  17. Pablo Gajate2,
  18. Cayetano Sempere-Ortega9,
  19. Elisabeth Jiménez-Aguilar4,
  20. M. Angela Aznar3,
  21. Aitana Calvo1,
  22. Pedro P. Lopez-Casas10,
  23. Salvador Martín-Algarra7,
  24. Miguel Martín1,
  25. Dominique Tersago10,,
  26. Marisol Quintero10, and
  27. Ignacio Melero3
  1. 1Medical Oncology Department, Instituto de Investigación Sanitaria Gregorio Marañón and CIBERONC, Madrid 28007, Spain.
  2. 2Medical Oncology Department, Hospital Ramón y Cajal, IRYCIS and CIBERONC, Madrid28034, Spain.
  3. 3CIMA and Clínica Universidad de Navarra and CIBERONC, Pamplona 31008, Spain.
  4. 4Medical Oncology Department, Hospital 12 de Octubre, Madrid 28041, Spain.
  5. 5Medical Oncology Department, Institut Català d’Oncologia, Barcelona 08908, Spain.
  6. 6Medical Oncology Department, Hospital Universitario Quirónsalud, Madrid 28223, Spain.
  7. 7Medical Oncology Department, Clínica Universidad de Navarra, Pamplona 31008, Spain.
  8. 8Radiology Department, Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain.
  9. 9Radiology Department, Hospital Ramón y Cajal, Madrid 28034, Spain.
  10. 10Highlight Therapeutics (formerly known as Bioncotech Therapeutics), Valencia 46980, Spain.
  1. *Corresponding author. Email: ivanpantic{at}hotmail.com
  • These authors contributed equally to this work.

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