Research ArticleCancer

Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors

See allHide authors and affiliations

Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eabb0391
DOI: 10.1126/scitranslmed.abb0391

Interfering with cancer

Many immunotherapies for cancer have emerged in recent years, but none are universally effective. One potential problem is the loss of interferon signaling in tumors, which impairs the effectiveness of both immune checkpoint blockade and cell-based therapies. Kalbasi et al. determined that both JAK1 and JAK2 signaling were essential for the success of immune checkpoint blockade, whereas cell-based therapy only required JAK1 function, which maintained sufficient interferon signaling. The authors showed that defective interferon signaling in tumors could be bypassed with the immunostimulatory compound BO-112. In a companion clinical trial, Márquez-Rodas et al. tested BO-112 in human patients with cancer, with or without immune checkpoint blockade.

View Full Text

Stay Connected to Science Translational Medicine