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Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

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Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eabb0152
DOI: 10.1126/scitranslmed.abb0152

Article Information

vol. 12 no. 565

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 24, 2020
  • Accepted for publication September 4, 2020
  • .

Author Information

  1. Anusha Kalbasi1,2,3,*,
  2. Mito Tariveranmoshabad1,,
  3. Kevin Hakimi1,,
  4. Sarah Kremer1,
  5. Katie M. Campbell4,
  6. Juan M. Funes2,
  7. Agustin Vega-Crespo4,
  8. Giulia Parisi4,
  9. Ameya Champekar4,
  10. Christine Nguyen1,
  11. Davis Torrejon4,
  12. Daniel Shin4,
  13. Jesse M. Zaretsky4,
  14. Robert D. Damoiseaux3,5,6,
  15. Daniel E. Speiser7,
  16. Pedro P. Lopez-Casas8,
  17. Marisol Quintero8 and
  18. Antoni Ribas2,3,4,5,9
  1. 1Department of Radiation Oncology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
  2. 2Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, CA 90095, USA.
  3. 3Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA.
  4. 4Division of Hematology-Oncology, Department of Medicine, UCLA, Los Angeles, CA 90095, USA.
  5. 5Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA.
  6. 6California NanoSystems Institute, UCLA, Los Angeles, CA 90095, USA.
  7. 7Department of Oncology, University of Lausanne, 1015 Lausanne, Switzerland.
  8. 8Highlight Therapeutics, Paterna 46980 (Valencia), Spain.
  9. 9Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.
  1. *Corresponding author. Email: anushakalbasi{at}mednet.ucla.edu
  • These authors contributed equally to this work.

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