Research ArticleNEURODEGENERATIVE DISEASES

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

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Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eaay0399
DOI: 10.1126/scitranslmed.aay0399

Article Information

vol. 12 no. 565

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 14, 2019
  • Resubmitted September 4, 2019
  • Accepted for publication March 31, 2020
  • .

Author Information

  1. Changyoun Kim1,*,
  2. Alexandria Beilina2,
  3. Nathan Smith2,3,
  4. Yan Li4,
  5. Minhyung Kim5,
  6. Ravindran Kumaran2,
  7. Alice Kaganovich2,
  8. Adamantios Mamais2,
  9. Anthony Adame6,
  10. Michiyo Iba1,
  11. Somin Kwon1,
  12. Won-Jae Lee7,
  13. Soo-Jean Shin7,
  14. Robert A. Rissman6,
  15. Sungyong You5,8,
  16. Seung-Jae Lee7,
  17. Andrew B. Singleton9,
  18. Mark R. Cookson2 and
  19. Eliezer Masliah1,*
  1. 1Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA.
  4. 4Protein/Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  5. 5Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  6. 6Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  7. 7Department of Biomedical Sciences, Neuroscience Research Institute, and Department of Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
  8. 8Samuel Oschin Comprehensive Cancer Institute, Cedars–Sinai Medical Center, Los Angeles, CA 90048, USA.
  9. 9Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  1. *Corresponding author. Email: changyoun.kim{at}nih.gov (C.K.); eliezer.masliah{at}nih.gov (E.M.)

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