Research ArticleNEURODEGENERATIVE DISEASES

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

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Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eaay0399
DOI: 10.1126/scitranslmed.aay0399

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Understanding microglia response to α-synuclein

α-Synuclein (α-syn) deposition is a major hallmark of several neurodegenerative diseases. α-Syn can induce microglia activation and subsequent neurodegeneration; however, the mechanisms mediating microglia response to α-syn are not completely elucidated. Now, Kim et al. show that neuron-released α-syn promotes activation of leucine-rich repeat kinase 2 (LRRK2) in rodent microglia via TLR2 that in turn triggered a proinflammatory cascade through activation of the immune transcription factor nuclear factor of activated T cells, cytoplasmic 2 (NFATc2). Inhibiting LRRK2 ameliorated neuropathology in a mouse model of synucleinopathy.

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