Research ArticleBioengineering

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

See allHide authors and affiliations

Science Translational Medicine  14 Oct 2020:
Vol. 12, Issue 565, eaax8005
DOI: 10.1126/scitranslmed.aax8005

Article Information

vol. 12 no. 565

Print ISSN: 
Online ISSN: 
  • Received for publication April 24, 2019
  • Accepted for publication September 8, 2020
  • .

Author Information

  1. Moran Yadid1,2,
  2. Johan U. Lind1,2,3,
  3. Herdeline Ann M. Ardoña1,
  4. Sean P. Sheehy1,2,
  5. Lauren E. Dickinson1,2,
  6. Feyisayo Eweje1,2,
  7. Maartje M.C. Bastings2,4,5,6,
  8. Benjamin Pope1,2,
  9. Blakely B. O’Connor1,
  10. Juerg R. Straubhaar7,
  11. Bogdan Budnik7,
  12. Andre G. Kleber8 and
  13. Kevin Kit Parker1,2,*
  1. 1Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  2. 2Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
  3. 3Department of Health Technology, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.
  4. 4Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  6. 6Ecole Polytechnique Federale Lausanne (EPFL), School of Engineering, Institute of Materials, Programmable Biomaterials Laboratory, Station 12, 1015 Lausanne, Switzerland.
  7. 7FAS Division of Science, Harvard University, Cambridge, MA 02138, USA.
  8. 8Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  1. *Corresponding author. Email: kkparker{at}


Article usage

Article usage: October 2020 to October 2020

Oct 202077511241504

Stay Connected to Science Translational Medicine