Contents
14 October 2020
Vol 12, Issue 565
Vol 12, Issue 565
Research Articles
- Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip
Endothelial extracellular vesicles containing cardioprotective proteins rescue engineered human cardiac tissue in an ischemia-reperfusion injury model.
- An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
The human albumin variant E505Q/T527M/K573P improves pharmacokinetics of protein-based drugs and facilitates transport across mucosal epithelia.
- Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration
Bioengineered autologous cartilage-bone ramus-condyle grafts enable temporomandibular joint regeneration in a clinically sized porcine model.
- Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors
Intratumoral BO-112 combined with systemic anti–PD-1 shows immunotherapeutic potential to control tumors in patients primarily refractory to anti–PD-1.
- Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma
Interferon-independent MHC class I induction restores T cell immunity.
- LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
LRRK2 modulates nucleus translocation of NFATc2 in microglia.
- Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
The protozoan parasite Giardia lamblia enhances bile secretion and microbiota–mediated bile acid deconjugation in mice, leading to growth impairment.
Editors' Choice
- Good sleep for healthy kidneys
Poor sleep shows potential causal relationship with risk of developing chronic kidney disease.
- Getting to the heart of bone loss
Heart attack leads to systemic bone loss in mice, indicating fracture risk as a clinical comorbidity of heart attack.
- Weekly insulin dosing: Are we there yet?
Once-weekly insulin is as efficacious as daily insulin.
About The Cover
ONLINE COVER Cardioprotective Cargo. This illustration depicts extracellular vesicles (yellow) homing to areas of injury on a human heart. Extracellular vesicles are small particles released from cells that contain proteins and nucleic acid cargo. Yadid et al. analyzed the protein content of vesicles derived from endothelial cells and studied the protective effects of these vesicles in human heart-on-chip cultures during ischemia-reperfusion injury. Vesicles secreted by endothelial cells supported cardiac tissue contraction and viability of injured heart-on-chip cultures and boosted their metabolic function, highlighting a potential cardioprotective role for vesicles. [CREDIT: MICHAEL ROSNACH/HARVARD UNIVERSITY]
