14 October 2020
Vol 12, Issue 565

About The Cover

Cover image expansion

ONLINE COVER Cardioprotective Cargo. This illustration depicts extracellular vesicles (yellow) homing to areas of injury on a human heart. Extracellular vesicles are small particles released from cells that contain proteins and nucleic acid cargo. Yadid et al. analyzed the protein content of vesicles derived from endothelial cells and studied the protective effects of these vesicles in human heart-on-chip cultures during ischemia-reperfusion injury. Vesicles secreted by endothelial cells supported cardiac tissue contraction and viability of injured heart-on-chip cultures and boosted their metabolic function, highlighting a potential cardioprotective role for vesicles. [CREDIT: MICHAEL ROSNACH/HARVARD UNIVERSITY]