Contents
07 October 2020
Vol 12, Issue 564
Vol 12, Issue 564
Research Articles
- Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study
Noninvasive bimodal neuromodulation reduces tinnitus symptom severity within 12 weeks of treatment for up to 12 months after completing treatment.
- Immunocytokines are a promising immunotherapeutic approach against glioblastoma
Immunocytokines display promising antitumor activity in orthotopic mouse models of glioma and patients with glioblastoma.
- Potential impact of tuberculosis vaccines in China, South Africa, and India
Tuberculosis vaccines should aim to protect infected populations against disease, but other vaccine types may be of use in high-transmission settings.
- ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist
Intestinal CD146+CCR5+ T cells activated by ICOSL+ plasmacytoid DCs during acute GVHD can be inhibited by a dual ICOS/CD28 antagonist.
- Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide
Pharmacological inhibition of AQP1 prevents H2O2 transport and hypertrophy of cardiac myocytes.
- Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Differences in immune responses to SARS-CoV-2 in children and adults are linked to clinical outcomes.
Editors' Choice
- Stimulating brain drug delivery
Neural activity affects how the blood-brain barrier regulates influx and efflux of agents between the blood and the central nervous system.
- Outsourcing glucose management to AI
An automated decision support tool could expand access to intensive insulin therapy for patients with type 1 diabetes.
- Single-cell transcriptomic architecture of endothelial cells
Single-cell transcriptomics reveals organ-specific identities and sex-specific differences of endothelial cells.
About The Cover
ONLINE COVER Resounding Relief. This illustration shows a neuromodulatory device used to treat tinnitus, a condition of perceived noise or ringing in the ears. Conlon et al. investigated the effects of acoustic stimulation (delivered by headphones) paired with electrical stimulation of the tongue in patients with chronic tinnitus. After 12 weeks of treatment, patients reported a reduction in symptom severity, which persisted for 12 months. These encouraging results support the therapeutic potential of noninvasive bimodal neuromodulation for tinnitus. [CREDIT: SCIENCEPICTURE CO., NEUROMOD DEVICES LTD.]
