Research ArticleAlzheimer’s Disease

Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

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Science Translational Medicine  30 Sep 2020:
Vol. 12, Issue 563, eaaz2541
DOI: 10.1126/scitranslmed.aaz2541

Article Information

vol. 12 no. 563

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 27, 2019
  • Accepted for publication May 6, 2020
  • .

Author Information

  1. Leah K. Cuddy1,
  2. Dmitry Prokopenko2,
  3. Eric P. Cunningham1,
  4. Ross Brimberry1,
  5. Peter Song1,
  6. Rory Kirchner3,
  7. Brad A. Chapman3,
  8. Oliver Hofmann4,
  9. Winston Hide5,
  10. Daniele Procissi6,
  11. Taleen Hanania7,
  12. Steven C. Leiser7,
  13. Rudolph E Tanzi2,* and
  14. Robert Vassar1,8,*
  1. 1Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  2. 2Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
  3. 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  4. 4Department of Clinical Pathology, University of Melbourne, Victoria 3000, Melbourne, Australia.
  5. 5Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  6. 6Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  7. 7PsychoGenics Inc., Paramus, NJ 07652, USA.
  8. 8Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  1. *Corresponding author. Email: r-vassar{at}northwestern.edu (R.V.); tanzi{at}helix.mgh.harvard.edu (R.E.T.)

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