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30 September 2020
Vol 12, Issue 563

About The Cover

Cover image expansion

ONLINE COVER An ACE up the Sleeve. This immunofluorescence image shows angiotensin-converting enzyme 1 (ACE1) expression (green) in the mouse brain. ACE1 has recently been identified as a risk factor for Alzheimer’s disease. Cuddy et al. identified ACE1 variants associated with Alzheimer’s disease in multiple cohorts of patients. Mechanistic analysis of one of these variants in a mouse model of Alzheimer’s disease showed that the variant increased ACE1 expression in neurons and induced severe neuropathology, particularly in female animals. Inhibiting ACE signaling with FDA-approved drugs reduced neurodegeneration in mice carrying this ACE1 variant, suggesting that ACE inhibitors could be repurposed for Alzheimer’s disease. [CREDIT: CUDDY ET AL./SCIENCE TRANSLATIONAL MEDICINE]