Contents
30 September 2020
Vol 12, Issue 563
Vol 12, Issue 563
Editorial
- Global approaches to genomic medicine implementation
A snapshot of implementation initiatives worldwide illustrates the need for collaboration to realize the full potential of genomic medicine.
Research Articles
- Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
Ace1 knockin mice have increased neuronal ACE1 and hippocampal neuron loss that is accelerated by Aβ and blocked by approved angiotensin pathway drugs.
- Exosomes derived from Vδ2-T cells control Epstein-Barr virus–associated tumors and induce T cell antitumor immunity
Exosomes from expanded allogeneic Vδ2-T cells kill EBV-associated tumors and promote antitumor immune responses.
- Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis
Up-regulation of FGFR3 and FGF9 induces profibrotic pathways promoting fibroblast activation and tissue fibrosis in systemic sclerosis.
- Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants
A new strain of the bacterium Paenibacillus contributes to postinfectious hydrocephalus in Ugandan infants.
- Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy
Anticancer therapeutic effects can be improved by directing immune checkpoint blockade antibodies to tumor-draining lymph nodes.
- Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase
Bicyclic azetidines potently inhibit Cryptosporidium in vivo by targeting phenylalanyl-tRNA synthetase.
Editors' Choice
- Quarterly picks from the editors
The Science Translational Medicine editors highlight interesting translational ties across select articles published recently in the Science family of journals.
- MIS-Cing pieces of the puzzle
Multisystem inflammatory syndrome in children associated with COVID-19 is distinct from other hyperinflammatory conditions in children.
- Signal autonomy: Skeletal muscle in diabetes
Skeletal muscle from individuals with type 2 diabetes has a cell-autonomous phosphoprotein signature.
- Uncovering metabolic states in cytotoxic T cells, one cell at a time
Single-cell metabolic state analysis reveals cytotoxic T cell activity patterns that are spatially organized in human colorectal tumors.
About The Cover
ONLINE COVER An ACE up the Sleeve. This immunofluorescence image shows angiotensin-converting enzyme 1 (ACE1) expression (green) in the mouse brain. ACE1 has recently been identified as a risk factor for Alzheimer’s disease. Cuddy et al. identified ACE1 variants associated with Alzheimer’s disease in multiple cohorts of patients. Mechanistic analysis of one of these variants in a mouse model of Alzheimer’s disease showed that the variant increased ACE1 expression in neurons and induced severe neuropathology, particularly in female animals. Inhibiting ACE signaling with FDA-approved drugs reduced neurodegeneration in mice carrying this ACE1 variant, suggesting that ACE inhibitors could be repurposed for Alzheimer’s disease. [CREDIT: CUDDY ET AL./SCIENCE TRANSLATIONAL MEDICINE]
