PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma

Tian-Yi Jiang; Yu-Fei Pan; Zheng-Hua Wan; Yun-Kai Lin; Bin Zhu; Zhen-gang Yuan; Yun-Han Ma; Yuan-Yuan Shi; Tian-Mei Zeng; Li-Wei Dong; Ye-Xiong Tan; Hong-Yang Wang

doi:10.1126/scitranslmed.aay0152

Research ArticleCancer

PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma

View ORCID ProfileTian-Yi Jiang¹,²,*,
View ORCID ProfileYu-Fei Pan²,³,*,
Zheng-Hua Wan²,*,
Yun-Kai Lin¹,²,
View ORCID ProfileBin Zhu⁴,
View ORCID ProfileZhen-gang Yuan⁴,
View ORCID ProfileYun-Han Ma¹,²,
Yuan-Yuan Shi¹,
View ORCID ProfileTian-Mei Zeng⁴,
View ORCID ProfileLi-Wei Dong ¹,³,†,
View ORCID ProfileYe-Xiong Tan²,³,† and
View ORCID ProfileHong-Yang Wang ¹,²,³,⁵,⁶,†

¹International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.
²National Center for Liver Cancer, Shanghai 201805, China.
³Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Shanghai 200438, China.
⁴Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
⁵State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
⁶Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Second Military Medical University & Ministry of Education, Shanghai 200438, China.

↵†Corresponding author. Email: dlw{at}smmu.edu.cn (L.-W.D.); yxtan1214{at}163.com (Y.-X.T.); hywangk{at}vip.sina.com (H.-Y.W.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 23 Sep 2020:
Vol. 12, Issue 562, eaay0152
DOI: 10.1126/scitranslmed.aay0152

Tian-Yi Jiang

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

2National Center for Liver Cancer, Shanghai 201805, China.

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Yu-Fei Pan

2National Center for Liver Cancer, Shanghai 201805, China.

3Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Shanghai 200438, China.

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Zheng-Hua Wan

2National Center for Liver Cancer, Shanghai 201805, China.

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Yun-Kai Lin

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

2National Center for Liver Cancer, Shanghai 201805, China.

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Bin Zhu

4Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.

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Zhen-gang Yuan

4Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.

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Yun-Han Ma

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

2National Center for Liver Cancer, Shanghai 201805, China.

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Yuan-Yuan Shi

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

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Tian-Mei Zeng

4Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.

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Li-Wei Dong

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

3Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Shanghai 200438, China.

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For correspondence: dlw@smmu.edu.cn yxtan1214@163.com hywangk@vip.sina.com

Ye-Xiong Tan

2National Center for Liver Cancer, Shanghai 201805, China.

3Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Shanghai 200438, China.

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For correspondence: dlw@smmu.edu.cn yxtan1214@163.com hywangk@vip.sina.com

Hong-Yang Wang

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China.

2National Center for Liver Cancer, Shanghai 201805, China.

3Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Shanghai 200438, China.

5State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

6Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Second Military Medical University & Ministry of Education, Shanghai 200438, China.

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ORCID record for Hong-Yang Wang
For correspondence: dlw@smmu.edu.cn yxtan1214@163.com hywangk@vip.sina.com

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PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma

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