Research ArticleRegenerative Medicine

Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats

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Science Translational Medicine  23 Sep 2020:
Vol. 12, Issue 562, eaax2992
DOI: 10.1126/scitranslmed.aax2992

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Enhancing engraftment

Cell transplant strategies to improve cardiac function after myocardial infarction are plagued by poor engraftment. Sun et al. showed that transplanting microvessels harvested from adipose tissue with cardiomyocytes derived from human induced pluripotent stem cells led to greater cell survival, tissue perfusion, myocyte maturation, and cardiac functional improvements in rats. Cotransplanting microvessels with other cell types could have broad applications for regenerative medicine beyond the cardiovascular system.

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