Research ArticleCORNEAL INJURY

Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews

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Science Translational Medicine  23 Sep 2020:
Vol. 12, Issue 562, eaaw1120
DOI: 10.1126/scitranslmed.aaw1120

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aMUSEment in sight

Scars from corneal injuries are a major cause of blindness. Stem cell therapy holds promises for treating corneal scarring; however, selecting the source of stem cells is critical for the positive outcome of the cell transplant. Here, Guo et al. evaluated the therapeutic potential of corneal stromal cells (CSCs) derived from multilineage-differentiating stress-enduring (Muse) cells isolated from lipoaspirate. Muse cells showed high stemness, activity, and proliferation. Transplant of Muse-derived CSCs promoted tissue regeneration and reduced scarring in models of corneal injury in mice and tree shrews. The results suggest that Muse-CSCs have therapeutic potential for treating corneal diseases.

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