Contents
23 September 2020
Vol 12, Issue 562
Vol 12, Issue 562
Editorial
- We’re on our own
The failure of U.S. government scientists in the Trump administration to follow the science around COVID-19 has left the medical community to fend for itself.
Research Articles
- Analysis of spatial osteochondral heterogeneity in advanced knee osteoarthritis exposes influence of joint alignment
Advanced human varus knee osteoarthritis correlates in a location-dependent and site-specific fashion with axial malalignment of the lower limb.
- Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma
KSP inhibition results in cell death through mitotic arrest and causes regression of neuroblastoma PDX tumors in mice.
- Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews
Corneal stromal cells differentiated from Muse spheroids had therapeutic effects on wounded corneas in mice and tree shrews.
- Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats
Microvessels enhance survival of hiPSC-derived cardiomyocytes, improving remuscularization and cardiac function after myocardial infarction in rats.
- A stepped-wedge randomized trial and qualitative survey of HIV pre-exposure prophylaxis uptake in the Eswatini population
Promoting HIV pre-exposure prophylaxis at primary care clinics in Eswatini led to an increase in uptake among at-risk adults.
- PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma
PTEN loss promotes the expression of genes encoding proteasome subunits and facilitates bortezomib chemosensitivity.
Editors' Choice
- Therapeutic microbubbles make tumor cells pop
Combining ultrasound release and molecular targeting selectively delivered extremely toxic and hydrophobic drugs to tumor cells.
- Building a better way to mend a broken heart
A novel hybrid pulsatile ventricular assist device uses an endothelialized pump surface to achieve biocompatibility.
- The trouble with tissue factor
A bleeding disorder due to genetic deficiency in tissue factor has been identified.
About The Cover
ONLINE COVER Observations in Osteoarthritis. This three-dimensional microcomputed tomography model depicts bone architecture in the medial region of the knee joint of a patient with osteoarthritis. Haberkamp et al. mapped joint malalignment and spatial load distribution in varus knee osteoarthritis, a condition of cartilage and bone degeneration in which the lower limbs deviate from axial alignment (bow-leggedness). Joint malalignment reduced load in the lateral region of the knee, which was compensated for by overload of the medial region. Markers of osteoarthritis were also decreased in the lateral region in comparison to the medial region. Incorporating joint alignment analysis in osteoarthritis assessment could detect location-dependent structural changes and identify strategies to rebalance load to prevent disease progression. [CREDIT: HABERKAMP ET AL./SCIENCE TRANSLATIONAL MEDICINE]
