16 September 2020
Vol 12, Issue 561

About The Cover

Cover image expansion

ONLINE COVER Mitigating Myocardial Infarction. This immunofluorescence image shows the border zone of porcine heart tissue treated with cardiac cell–derived exosomes after myocardial infarction. Cell therapy is mediated in part by factors secreted from transplanted cells, which are contained in exosomes. Gao et al. compared transplant of a mixture of cardiomyocytes, smooth muscle cells, and endothelial cells derived from human induced pluripotent stem cells to exosomes purified from these cells or fragmented cells in pigs after myocardial infarction. Treatments improved cardiac function and limited hypertrophy without increasing arrhythmia, suggesting exosome transplant could have potential as an acellular therapy for cardiovascular disease. [CREDIT: GAO ET AL./SCIENCE TRANSLATIONAL MEDICINE]